Endocrine Abstracts

Objective: To evaluate the efficacy of canagliflozin 100 mg for glycemic control and progression of weight loss after stabilization with liraglutide 1.8 mg.Patients and methods: Descriptive study: patients with type 2 diabetes (DM-2) in treatment with metformin and liraglutide 1.8 mg, optimal metabolic control, which after stabilization in weight loss, liraglutide is suspended and canagliflozin 100 mg is added. Variables analyzed baseline and at 6 months...

Objetive: The change of treatment of liraglutide 1.8 mg to dapagliflozin or canaglifonzin 100 mg in patients with optimal glycemic control and stabilization weight loss, achieves progression in weight loss and improves the metabolic control of the patient with tipo 2 diabetes (DM-2). Our objective is to evaluate if there are differences in metabolic control and progression of weight loss in patients treated with canagliflozin 100 mg or dapagliflozin.Pati...

Introduction: Obesity is a major health problem and a risk factor for the development of other diseases. However, there are morbid obese subjects of long evolution that can be considered metabolically healthy obese, whose existence is in doubt for many clinicians.Objetive: To analyze if there are differences in cardiovascular risk between metabolically healthy (MHO) and sick obese (MSO), matched by age, sex and body mass index (BMI).<p class="abstext...

We present the case of a 24-year-old melanodermic male patient from Angola referred to the Endocrinology department of a central hospital, in Lisbon, Portugal. He presented skeletal deformities and joint laxity, and numerous mucosal neuromas of the oral cavity since early childhood. Recurrent diarrhea was also reported but elevated blood pressure was not observed at that time. Multinodular goiter (nodules>40 mm) was identified in physical examination and microcalcification...

Acromegaly is caused by excessive growth hormone (GH) secretion from pituitary adenomas. Transphenoidal surgery is the first-choice treatment, but new drug therapies (e.g. somatostatin analogs, SSA) offer promising avenues for medical treatment. Complementary diagnostic tools may assist this strategy, helping to refine drug choice. Here, we investigate the associations between postsurgical radiological features and molecular phenotype of pituitary tumors from acromegalic patie...

Introduction, material and methods: Papillary thyroid cancer is well known to be a tumour with a good prognosis; in spite of that, it usually presents many recurrences that increases its morbidity. Follicular thyroid cancer is less frequent but has a higher rate of hematogenous dissemination and higher mortality than papillary thyroid cancer. We have collected the data of our patients with differentiated thyroid cancer during the period from 2000 to 2015. In this study, we hav...

Introduction: Although thyrotoxicosis is considered to be a very rare finding in a patient with thyroid cancer, there are several reports regarding this unexpected association in specialty literature. A frequent cause of thyrotoxicosis in patients with cardiac disease is amiodarone-induced thyroid dysfunction. The mechanism underlying this adverse reaction can be attributed to high iodine content and the direct toxic effect of the drug on thyroid cells.C...

Adult-onset hypopituitarism is a frequently delayed diagnosis because of the insidious debut and non-specific symptoms, frequently attributed to normal aging or many other pathologies - fatigue, malaise, cognitive impairment, decreased libido. Left untreated, it can have severe consequences with vital impact.Case-report: We present the case of a female patient, aged 69, who was initially addressed for evaluation of hypercalcemia. She had had four live bi...

IntroductionTypical bronchial carcinoids (TBC) are rare well-differentiated neuroendocrine neoplasms (NEN) of the lung whose management can still be very challenging. In fact, the gold-standard treatment for TBC is total resection of the primary tumour; however, in case of metastatic disease adjuvant therapy with the mTOR inhibitor everolimus (eve) might be recommended. Unfortunately, prognosis may be very poor in cases showing moderate response rates to...

IntroductionThe toxic solitary thyroid nodule is a major cause of hyperthyroidism, especially in iodine-deprived regions. The most widely used therapy is iodine-131, which is effective in achieving normal thyroid function and reducing nodule dimensions, however, it may induce hypothyroidism. The aim of this study was to evaluate the outcomes of radioiodine therapy in patients with toxic solitary nodules and to determine predictive factors for the develop...